A CONSERVED ACIDIC RESIDUE IN THE C-TERMINAL FLEXIBLE LOOP OF HIV-1 NEF CONTRIBUTES TO THE ACTIVITY OF SERINC5 AND CD4 DOWNREGULATION

A Conserved Acidic Residue in the C-Terminal Flexible Loop of HIV-1 Nef Contributes to the Activity of SERINC5 and CD4 Downregulation

The host transmembrane protein SERINC5 is incorporated into retrovirus particles and inhibits HIV-1 infectivity.The lentiviral Nef protein counteracts SERINC5 by downregulating it from the cell surface and preventing its incorporation into virions.The ability of Nef to antagonize the host factor varies in magnitude between different HIV-1 D Vitamin

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Fraud Detection Using Neural Networks: A Case Study of Income Tax

Detecting tax fraud is a top objective for practically all tax agencies in order to maximize revenues and maintain a high level of compliance.Data mining, machine learning, and other approaches such as traditional random auditing have been used in many studies to deal with tax fraud.The goal of this study is to use Artificial Neural Networks to ide

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Determinants of station-based round-trip bikesharing demand

First and last mile connectivity of public transport hubs is a key component in promoting multi-modal travel.The Dutch train station operator (NS Stations) promotes the combination of bike and train by offering a train station-based round-trip bikesharing (SBRT) scheme, known as ‘OV-fiets’, located at train stations throughout the country.This

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